The Zika virus (ZIKV) nonstructural protein 1 (NS1) is a multifunctional glycoprotein essential for viral replication, immune modulation, and pathogenesis. NS1 exists as a membrane-associated dimer within replication complexes and as a secreted hexamer that circulates in host serum, where it disrupts vascular integrity and complement activation. Structurally, NS1 comprises three conserved domains—the β-roll, wing, and β-ladder—that mediate oligomerization and host interactions. Functionally, NS1 stabilizes the viral replication machinery and suppresses type I interferon signaling, facilitating immune evasion. Its early secretion during infection makes NS1 a sensitive biomarker for ZIKV detection and epidemiological surveillance. Catalina’s Zika virus NS1 antibodies provide high specificity and reproducibility, supporting advanced research in virology, immunopathogenesis, and vaccine development.