Angiotensin-converting enzyme 2 (ACE2) is a type I transmembrane metalloprotease critical for regulating the renin–angiotensin system (RAS). By converting angiotensin II into Ang(1–7), ACE2 maintains vascular tone, reduces inflammation, and supports tissue homeostasis. ACE2 is highly expressed in the lungs, heart, kidneys, intestines, and brain, playing essential roles in cardiovascular, pulmonary, renal, and neurological homeostasis. It is also the primary receptor for SARS-CoV-2, making it a central focus in COVID-19, virology, and immunology research. ACE2 antibodies are indispensable tools for studying protein expression, cellular localization, and interactions with viral spike proteins. Catalina’s validated ACE2 antibodies deliver reproducible results and support research in viral entry, neutralization assays, vaccine development, and therapeutic antibody screening. With high sensitivity and specificity, these antibodies are essential tools for basic research, translational studies, and diagnostic assay development.