Apolipoprotein E (ApoE) is a lipid-transporting glycoprotein that plays a critical role in cholesterol metabolism, neuronal maintenance, and vascular function. The APOE gene encodes three isoforms (i.e., ε2, ε3, and ε4) with ε4 being the strongest genetic risk factor for late-onset Alzheimer’s disease (AD) and ε2 offering protective effects. ApoE contributes to amyloid-β aggregation, tau pathology, synaptic dysfunction, and neuroinflammation, making it a central target for Alzheimer’s research, neurodegeneration studies, and lipid metabolism investigations. Antibodies against ApoE allow detection of protein expression, isoform-specific analysis, and investigation of amyloid plaque formation in brain tissue. Catalina’s validated ApoE antibodies are stringently validated and support studies in neurobiology, atherosclerosis, cardiovascular disease, biomarker validation, and therapeutic development with reproducible, high-sensitivity results. These antibodies are indispensable tools for researchers exploring Alzheimer’s disease mechanisms and lipid-associated pathologies.