Insulin-like Growth Factor-2 (IGF-2) is a secreted growth factor encoded on chromosome 11p15.5, critical for fetal development and tightly regulated by genomic imprinting. Dysregulation of IGF2 expression, often through loss of imprinting, leads to aberrant activation of proliferative pathways. IGF-2 signals via IGF1R and insulin receptor isoform A (IR-A), stimulating PI3K-Akt and MAPK/ERK cascades to drive uncontrolled growth, angiogenesis, and survival. Overexpression of IGF-2 is strongly linked to hepatocellular carcinoma, colorectal cancer, breast cancer, and lung cancer, as well as therapy resistance and cancer stemness. Catalina’s IGF-2 antibodies deliver high specificity and performance for accurate detection and characterization of this critical growth factor. IGF-2 antibodies are invaluable for researchers in cancer biology, endocrinology, and metabolic disease, supporting both basic investigations and translational applications.