Thrombospondin-2 (TSP-2), encoded by THBS2, is a secreted matricellular glycoprotein that regulates extracellular matrix organization, collagen fibrillogenesis, and angiogenesis. Elevated TSP-2 expression is closely associated with hepatic fibrosis, cirrhosis, and the progression of multiple malignancies, including pancreatic and colorectal cancers. Functionally, TSP-2 modulates matrix metalloproteinase activity, immune cell infiltration, and metabolic signaling within the tumor microenvironment, positioning it as a critical mediator of tissue remodeling and disease progression. Catalina’s TSP-2 antibodies deliver high specificity and reproducibility, providing reliable tools for studies in fibrosis, cancer biology, extracellular matrix dynamics, and translational research.