Metabolism refers to the conserved catabolic and anabolic pathways that sustain energy balance and macromolecular synthesis while endocrinology involves the study of hormones. Nutritional imbalances, organ dysfunction, and genetic variants can disrupt the intricate interplay between these entities and drive disorders such as diabetes, dyslipidemia, and osteoporosis. Advancing metabolic and endocrine research is essential for improving the clinical management of metabolic and endocrine disorders.