The ASFV p54 protein is an essential structural component of the African Swine Fever Virus (ASFV) envelope, mediating viral attachment and internalization into host cells. Beyond its structural role, p54 actively contributes to immune evasion by suppressing type I interferon signaling, thereby promoting viral persistence and pathogenesis. Due to these functions, p54 is considered a key molecular target for ASFV diagnostics, antiviral drug development, and vaccine design. Catalina offers high-affinity ASFV p54 antibodies validated for sensitive detection and quantitative analysis of p54 expression in ASFV-infected cells and tissues, supporting mechanistic studies of viral replication, host–pathogen interactions, and immune modulation.