The Dengue virus (DENV) non-structural protein 1 (NS1) is a secreted glycoprotein essential for viral replication and immune evasion and is a well-established biomarker for early dengue infection. Circulating NS1 is detectable prior to IgM seroconversion and is strongly associated with severe disease manifestations, including vascular leakage and endothelial dysfunction, through immune activation and disruption of vascular integrity. Targeting NS1 with monoclonal antibodies enables sensitive detection and offers therapeutic potential by neutralizing NS1-mediated pathogenic effects. Catalina’s high-quality DENV NS1 antibodies provide exceptional specificity and reproducibility, supporting advanced research in virology, immunopathogenesis, vaccine development, and therapeutic antibody discovery.